Vascular delivery devices

ABSTRACT

A vascular method is disclosed comprising introducing a first flexible wire into a blood vessel, wherein the blood vessel has a first vessel end and a second vessel end and wherein the first flexible wire has a first end and a second end, sliding an angiotip along the first flexible wire in a direction away from the first end of the wire and toward the second end of the wire, frictionally engaging the first flexible wire with the angiotip, and pulling the first flexible wire through the blood vessel in the direction of the second vessel end, wherein the pulling of the first flexible wire pulls the angiotip through the blood vessel in the direction of the second vessel end.

This application is a continuation of, and claims benefit of, U.S.application Ser. No. 13/269,996, filed Oct. 10, 2011, now U.S. Pat. No.9,005,266, which is hereby incorporated by reference in its entirety.

BACKGROUND

1. Field of Inventions

The field of this application and any resulting patent is vasculardelivery methods.

2. Description of Related Art

This application and any patent issuing therefrom relates to vasculardelivery methods including methods for delivering cardiovasculardevices. Endovascular surgery has revolutionized the treatment ofcardiovascular disease. Most cardiovascular disease is now treated withdevices which are pushed into place over a wire. Patients now enjoyminimally invasive repair of cardiovascular disease without painfulincisions. However, extreme vessel tortuosity and stenosis can bedangerous in the placement of ever larger devices into blood vessels.

Various methods and devices have been proposed and utilized to deliver acardiovascular device to a target location, including the methods anddevices disclosed in the patents appearing on the face of this patent.However, these methods and devices lack all the steps or features of themethods and devices covered by the patent claims below, and the methodsand structures claimed in this issued patent solve many of the problemsfound in many of the methods and structures in those earlier patents,have unpredictable benefits, and overcome shortcomings inherent in thoseearlier methods and structures.

SUMMARY

One or more specific embodiments disclosed herein includes a vascularmethod comprising (including): introducing a first flexible wire into ablood vessel, wherein the blood vessel has a first vessel end and asecond vessel end and wherein the first flexible wire has a first endand a second end, sliding an angiotip along the first flexible wire in adirection away from the first end of the wire and toward the second endof the wire, frictionally engaging the first flexible wire with theangiotip, and pulling the first flexible wire through the blood vesselin the direction of the second vessel end, wherein the pulling of thefirst flexible wire pulls the angiotip through the blood vessel in thedirection of the second vessel end.

One or more specific embodiments disclosed herein includes a surgicalmethod preferably comprising: introducing a first flexible wire into ablood vessel, wherein the blood vessel has a first vessel end and asecond vessel end and wherein the first flexible wire has a first endand a second end; sliding an angiotip along the first flexible wire in adirection away from the first end of the wire and toward the second endof the wire; applying a brake to the first flexible wire; and pullingthe first flexible wire through the blood vessel in the direction of thesecond vessel end, wherein the pulling of the first flexible wire pullsthe angiotip through the blood vessel in the direction of the secondvessel end.

One or more specific embodiments disclosed herein includes a surgicaldevice preferably comprising: a first flexible wire; an angiotipcomprising an inner cavity; and a brake capable of limiting the movementof the first flexible wire in the longitudinal directions within theinner cavity of the angiotip.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a simplified side view of several elements found in oneexample of an assembled vascular delivery system.

FIG. 2A is a cut-away side view of an angiotip and other elements ofFIG. 1 in the unlocked position.

FIG. 2B is a cut-away side view of an angiotip and other elements ofFIG. 1 in the locked position.

FIG. 3 is a simplified side view of several elements found in oneexample of an assembled vascular delivery system.

FIG. 4 is a cut-away side view of an angiotip and other elements of FIG.3 in the unlocked position.

FIG. 5 is a simplified side view of several elements found in oneexample of an assembled vascular delivery system.

FIG. 6A is a cut-away side view of an angiotip and other elements ofFIG. 5 in the unlocked position.

FIG. 6B is a cut-away side view of an angiotip and other elements ofFIG. 5 in the locked position.

FIG. 7 is a simplified side view of several elements found in oneexample of an assembled vascular delivery system.

FIG. 8 is a cut-away side view of an angiotip and other elements of FIG.7.

FIG. 9A is a simplified top view of a body with a guide wire insertedinto a blood vessel.

FIG. 9B is a simplified top view of a body with an angiotip and devicepartially advanced along a guide wire within a blood vessel.

FIG. 9C is a simplified top view of a body with a locking wire insertedthrough a blood vessel to an angiotip.

FIG. 9D is a simplified top view of a body depicting further advancementof an angiotip and device due to engagement of the angiotip and guidewire and movement of the guide wire and angiotip such that the angiotipis advanced to a target site.

DETAILED DESCRIPTION 1. Introduction

A detailed description will now be provided. The purpose of thisdetailed description, which includes the drawings, is to satisfy thestatutory requirements of 35 U.S.C §112. For example, the detaileddescription includes disclosure of the inventor's best mode ofpracticing the inventions, a description of the inventions, andsufficient information that would enable a person having ordinary skillin the art to make and use the inventions referenced in the claims. Inall the figures, like elements are indicated by like reference numeralsregardless of the view in which the elements appear. The figures areintended to assist the description and to provide a visualrepresentation of certain aspects of the subject matter describedherein. Those figures are not drawn to scale, nor are they intended toshow all the structural details of the pulling methods and apparatuses,nor to limit the scope of the claims.

Each of the appended claims defines a separate invention, which forinfringement purposes is recognized as including equivalents of thevarious elements or limitations specified in the claims. Depending onthe context, all references below to the “invention” may in some casesrefer to certain specific embodiments only. In other cases, it will berecognized that references to the “invention” will refer to the subjectmatter recited in one or more, but not necessarily all, of the claims.Each of the inventions will now be described in greater detail below,including specific embodiments, versions, and examples, but theinventions are not limited to these embodiments, versions, or examples,which are included to enable a person having ordinary skill in the artto make and use the inventions, when the information in this patent iscombined with available information and technology. Various terms asused herein are defined below, and the definitions should be adoptedwhen construing the claims that include those terms, except to theextent a different meaning is given within the specification or inexpress representations to the Patent and Trademark Office (PTO). To theextent a term used in a claim is not defined below, or inrepresentations to the PTO, it should be given the broadest definitionpersons in the pertinent art have given that term as reflected inprinted publications, dictionaries, and issued patents.

2. Selected Definitions

Certain claims include one or more of the following terms, which, asused herein, are expressly defined as follows.

The term “angiotip” (ANGIOTIP is claimed to be a trademark of Endologix,Inc.) is broadly defined herein as a housing comprising at least oneinner cavity capable of containing at least a portion of a wire and atleast one opening at one end (e.g. distal end) for the wire. The housingis preferably made of plastic and has a proximal lateral face and adistal lateral face that are substantially perpendicular to the parallelportions of the longitudinal sides of the housing. The housing may bebeveled longitudinally on the distal end, so that the distal face has asmaller surface area than the proximal face. Preferably, at least aportion of an inner cavity surface is parallel with the non-beveledportions of the longitudinal walls of the housing. The inner cavitypreferably comprises an inner cavity surface, a distally positionedopening, and a proximal positioned opening. In some specificembodiments, the inner cavity may be capable of containing portions ofmore than one wire, and portions of the inner cavity surface may not beparallel with the non-beveled portions of the longitudinal walls of thehousing. For example, the inner cavity may be capable of containing ajamming lock wire as well as a guide wire, and a portion of the innercavity may be angled to direct the jamming lock wire radially againstthe guide wire. In some specific embodiments, the inner cavity may notbe concentric with the housing, but may be positioned closer to one sideof the longitudinal walls of the housing. For example, an inner cavitythat is capable of containing a braided locking wire and guide wire maynot be concentric with the housing.

The terms “proximal” and “distal” are terms that are used in the samecontext to describe the orientation and/or movement of the angiotip,guide wire, device, catheters, sheaths, vessels, and various specificembodiments of locking wires relative to one another and a point oforigin. The terms “proximal” and “distal” are terms relative to oneanother based on their positions relative to a point of origin or adefined reference point. The term “distal” is defined as any pointfarther from the point of origin or other reference point than a“proximal” point. The term “proximal” is defined as any point closer tothe point of origin or other reference point than a “distal” point. Thepoint where the angiotip is to be introduced to the body or has beenintroduced to the body may act as a point of origin when no otherreference point is defined.

The term “inner cavity” is broadly defined herein as any open cavity orother open area located within a structure (e.g. an angiotip).Preferably, an inner cavity has two openings through the structure tothe surrounding environment, and the path between the two openings is oris capable of being substantially unobstructed. An example of an innercavity includes a channel. An inner cavity is capable of containing alength of wire such that the wire may move freely through the openingsand within the inner cavity. In some specific embodiments, an innercavity may also contain elements necessary for applying a frictionalforce on a wire, but the wire may still be capable of moving freelywithin the inner cavity. For example, a twisting lock may be housedwithin an inner cavity, but a wire may still pass freely through theinner cavity. Alternatively, an inner cavity of a housing may becomprised of a twisting lock and an inner cavity surface of the housing.In some specific embodiments, an inner cavity comprises an inner cavitysurface with a single, edgeless, cylindrical face which directlyconnects the openings. In some specific embodiments, an inner cavity maycomprise an inner cavity surface with multiple faces that abut in a wayto directly connect the openings. For example, one of the faces may be aface angled toward one of the openings so when a wire presses againstthe face, it is directed towards the opening.

The term “frictionally engaging” is broadly defined herein as causingany direct or indirect physical contact between two structures orsurfaces and preferably resulting in some resistance to movement ofeither structure or surface. Preferably, the resistance to movement iscaused by the pressing of one surface against another, so when onesurface is pressed against another surface, the two surfaces arefrictionally engaged. In some specific embodiments, a wire may pressagainst a housing to limit the independent movement of both the wire andthe housing. In some specific embodiments, a lock that is positionedwithin and coupled to the housing may press against a wire, such thatthe lock is directly frictionally engaging the wire. In this situation,the housing and the wire are also frictionally engaged, by nature of thelock being coupled to and positioned within the housing.

The term “pressing” is broadly defined herein as an exerting of physicalforce upon an object. A pressing force does not need to beunidirectional or involve direct physical contact between one object andanother object that is pressed. In some specific embodiments, an objectmay be sandwiched between two other objects, such than pressing upon oneof the outer objects causes the middle object to press upon the otherouter object. In some specific embodiments, pressing may be caused bytwo adjacent objects being positioned within a housing that has an innercavity portion that is smaller than the size of the two objectstogether. In some specific embodiments, one object may encounter anangled surface that directs the object to press against another object.In some specific embodiments, a first object that encircles a secondobject may contract around the second object to press against it fromall sides.

The term “wire” is broadly defined herein as an elongated (preferablytubular) member that is flexible and capable of being bent by humanhands to a substantial degree (e.g., at least 30°) without breaking.Preferably, such a wire comprises steel and is capable of navigatingthrough tortuous blood vessels without breaking Preferably, such a wireis between 0.012 inches and 0.038 inches in diameter. In some specificembodiments, a preferred wire size is 0.018 inches in diameter. In somespecific embodiments, a preferred wire size is 0.035 inches in diameter.In some specific embodiments, the preferred wire size is 0.012 inches indiameter. In some specific embodiments, the preferred wire size is 0.014inches in diameter. The word “first” is used only to differentiate oneflexible wire from another flexible wire and should not be interpretedas defining a limitation on order or position of two wires. As is wellknown in the art, a wire initially introduced into the body may bereplaced by other wires, any of which may be referred to as the “firstflexible wire” of the claims if an angiotip is subsequently slid alongit. Similarly, a “second flexible wire” simply refers to another wirebesides the first flexible wire. The word “second” is used only todifferentiate one flexible wire from another flexible wire and shouldnot be interpreted as defining a limitation on order or position. Afirst flexible wire may be strong enough to pull an object's weightthrough a vessel as well as withstanding the frictional forces betweenthe object and the vessel. Depending on its context, the term “wire” mayrefer to an entire wire, e.g. from one end of the wire to the other end,or to a portion of an entire wire, e.g. from a distal point of the wireto a proximal point.

The term “guide wire” is broadly defined herein as any wire capable ofsupporting objects which may be directed along at least a portion of itslength. Preferably, a guide wire is capable of being used to navigatehollow objects through tortuous blood vessels. A guide wire may bepositioned to run through a designated target site and may be capable ofnavigating hollow objects along at least a portion of its length to thetarget site.

The term “coupled to” is broadly defined herein as being integral with(part of) or being directly or indirectly attached to. Preferably, afirst object coupled to a second object will cause the two objects tomove as a single unit. In some specific embodiments, an angiotip may becoupled to a brake so that applying the brake to a wire results infrictional engagement of the brake with the wire, as well as frictionalengagement of the angiotip with the wire. In some specific embodiments,a proximal lock may be used to couple an angiotip to a cardiovasculardevice, so as to cause the angiotip and cardiovascular device to move asa single unit.

The term “limiting the movement” is broadly defined herein as reducingor eliminating an object's capability to move relative to anotherobject. Preferably, movement relative to a second object is eliminated;however, in some specific embodiments, movement relative to a secondobject may be reduced, such that movement of the first object relativeto the second object takes more force to traverse a particular distancethan force required to move the same distance prior to the limiting ofthe first object. For example, frictionally engaging an angiotip with aguide wire may limit movement of the angiotip relative to the guidewire, so that movement of the 2 objects is no longer independent.

The term “brake” is broadly defined herein as any structure thatqualifies as a “brake” in the field of mechanics (seewww.dictionary.com). Preferably, the brake referenced in the claims iscapable of physically interacting with another object to directly,indirectly, or both indirectly and directly create a frictional force onthe other object, e.g. on its surface. In some specific embodiments, abrake is a second wire introduced into an inner cavity of a housing witha first wire, wherein a portion of the inner cavity has an angledsurface that directs the second wire against the first wire. In thissituation, the second wire directly creates a frictional force betweenthe surfaces of the first and second wires; the second wire alsoindirectly creates a frictional force by the second wire pressing thefirst wire against the inner cavity surface of the housing, thuscreating friction directly between the first wire and the inner cavitysurface. In some specific embodiments, a brake may be a second wireintroduced into an inner cavity of a housing with a first wire, whereinthe second wire is capable of being expanded to press against the firstwire. In this situation, the second wire directly creates a frictionalforce between the surfaces of the first and second wires; the secondwire also indirectly creates a frictional force by the second wirepressing the first wire against the inner cavity surface of the housing,thus creating friction directly between the first wire and the innercavity surface. In some specific embodiments, a brake may be a twistinglock coupled to a housing that surrounds a wire, wherein the twistinglock is capable of pressing against the wire from all sides. In thissituation, the twisting lock directly creates a frictional force betweenthe twisting lock and the wire. In some specific embodiments, a brakemay be a cam lock positioned within a housing, wherein the cam lock maybe actuated to press a wire against the inner cavity surface of thehousing. In this situation, the cam lock directly creates a frictionalforce between the surfaces of the cam lock and wire; the cam lock alsoindirectly creates a frictional force by the cam lock pressing the wireagainst the inner cavity surface of the housing, thus creating frictionbetween the wire and the inner cavity surface.

The term “cardiovascular device” is broadly defined herein as any objectthat can be used as a tool in cardiovascular surgery for treatment,diagnostics, or exploration. The object may remain in the body after thesurgery or may be removed subsequent to its use. Examples ofcardiovascular devices include vascular endografts, transcatheter aorticvalves, stents, balloons, tools for use in an atherectomy, intravascularimaging systems and other devices that are well known in the art.

The term “disposing against” is broadly defined herein as placing anobject adjacent to and in direct or indirect physical contact withanother object, such that the first object can be pressed against theother object. For example, a first wire may be disposed against a secondwire so that the two wires are in direct contact with one another withinan inner cavity of a housing. Preferably, by disposing the first wireagainst the second wire, the second wire may be directed to pressagainst the inner cavity surface of the housing.

The term “twisting lock” is broadly defined herein as any structurecapable of being rotated clockwise or counterclockwise around its axisto cause its inner diameter, e.g. of a compressed gasket, to contract.Contraction of the inner diameter of the structure may result in thepressing of an inner diameter surface against an object that residesinside the inner diameter of the structure. The structure may then berotated in the opposite direction to dilate the inner diameter to itsprevious size and release the pressure on the object that may haveresided within the inner diameter.

The term “blood vessel” is broadly defined herein as any elongatedstructure positioned within an organism comprising a lumen whose primaryfunction is transporting blood cells. A blood vessel may be branched. Ablood vessel comprises a vessel distal end and a vessel proximal endwhich are described relative to one another and relative to a point oforigin. The vessel distal end refers to the portion of the blood vesselfurther from a device's point of entry in the blood vessel lumen thanthe vessel proximal end.

The term “proximal lock” is broadly defined herein as any lock device,preferably one capable of coupling together independent parts of acardiovascular delivery system. In some specific embodiments, a proximallock is capable of preventing accidental deployment of a cardiovasculardevice from within its sheath, catheter, or other containing structure.A proximal lock may be positioned along a wire outside the body.Alternatively, a proximal lock may be positioned along a wire within thebody at a location proximal to an angiotip.

3. Certain Specific Embodiments

Now, certain specific embodiments are described, which are by no meansan exclusive description of the “invention.” Other specific embodiments,including those referenced in the drawings, are encompassed by thisapplication, and any patent that issues therefrom.

One or more specific embodiments disclosed herein includes a vascularmethod preferably comprising: introducing a first flexible wire into ablood vessel, wherein the blood vessel has a first vessel end and asecond vessel end and wherein the first flexible wire has a first endand a second end; sliding an angiotip along the first flexible wire in adirection away from the first end of the wire and toward the second endof the wire; frictionally engaging the first flexible wire with theangiotip; and pulling the first flexible wire through the blood vesselin the direction of the second vessel end, wherein the pulling of thefirst flexible wire pulls the angiotip through the blood vessel in thedirection of the second vessel end.

In any of the methods or structures disclosed herein, the first flexiblewire's first end is preferably a proximal wire end, and the firstflexible wire's second end is preferably a distal wire end.

In any of the methods or structures disclosed herein, the angiotippreferably has an inner cavity and an inner cavity surface.

In any of the methods or structures disclosed herein, the first flexiblewire is preferably a guide wire.

In any of the methods or structures disclosed herein, the first flexiblewire preferably has a diameter ranging from 0.014 inches to 0.038inches.

In any of the methods or structures disclosed herein, a vascular deviceis preferably introduced into the blood vessel.

In any of the methods or structures disclosed herein, the vasculardevice is preferably capable of being coupled to the angiotip by aproximal lock.

In any of the methods or structures disclosed herein, frictionallyengaging the first flexible wire with the angiotip preferably includespressing together the first flexible wire and the inner cavity surface.

In any of the methods or structures disclosed herein, the angiotippreferably has an inner cavity and an inner cavity surface, the firstflexible wire preferably includes a first wire portion disposed withinthe inner cavity, a second flexible wire is preferably introduced to theinner cavity of the angiotip, and frictionally engaging the firstflexible wire with the angiotip preferably includes disposing the secondflexible wire against the first flexible wire to cause the first wireportion to press against the inner cavity surface.

One or more specific embodiments disclosed herein includes a surgicalmethod preferably comprising: introducing a first flexible wire into ablood vessel, wherein the blood vessel has a first vessel end and asecond vessel end and wherein the first flexible wire has a first endand a second end; sliding an angiotip along the first flexible wire in adirection away from the first end of the wire and toward the second endof the wire; applying a brake to the first flexible wire; and pullingthe first flexible wire through the blood vessel in the direction of thesecond vessel end, wherein the pulling of the first flexible wire pullsthe angiotip through the blood vessel in the direction of the secondvessel end.

In any of the methods or structures disclosed herein, the angiotippreferably has an inner cavity and an inner cavity surface, and applyingthe brake to the first flexible wire preferably causes the firstflexible wire to press against the inner cavity surface of the angiotip.

In any of the methods or structures disclosed herein, applying the braketo the first flexible wire preferably includes causing the brake topress circumferentially against the first flexible wire.

In any of the methods or structures disclosed herein, the angiotippreferably has an inner cavity and an inner cavity surface, the brake ispreferably a second flexible wire, and applying the brake to the firstflexible wire preferably includes disposing the second flexible wireagainst the first flexible wire to cause the first wire portion to pressagainst the inner cavity surface.

In any of the methods or structures disclosed herein, the brake ispreferably applied to the first flexible wire within the angiotip.

One or more specific embodiments disclosed herein includes a surgicaldevice preferably comprising: a first flexible wire; an angiotipcomprising an inner cavity; and a brake capable of limiting the movementof the first flexible wire in the longitudinal directions within theinner cavity of the angiotip.

In any of the methods or structures disclosed herein, the angiotippreferably includes at least one proximal opening and at least onedistal opening through which the first flexible wire is capable ofpassing.

In any of the methods or structures disclosed herein, the angiotippreferably has an inner cavity surface, and the brake is preferablycapable of pressing the first flexible wire against the inner cavitysurface of the angiotip.

In any of the methods or structures disclosed herein, the angiotippreferably has an inner cavity surface, and the brake preferablycomprises a second flexible wire capable of pressing the first flexiblewire against the inner cavity surface of the angiotip.

In any of the methods or structures disclosed herein, the combineddiameters of the first flexible wire and the second flexible wire arepreferably greater than the diameter of the inner cavity of theangiotip.

In any of the methods or structures disclosed herein, the combineddiameters of the first flexible wire and the second flexible wire arepreferably capable of being greater than the diameter of the innercavity of the angiotip.

In any of the methods or structures disclosed herein, the brakepreferably comprises a twisting lock disposed within the inner cavity ofthe angiotip, the twisting lock capable of pressing the first flexiblewire.

In any of the methods or structures disclosed herein, the brakepreferably comprises a second flexible wire capable of pressing againstthe first flexible wire.

In any of the methods or structures disclosed herein, the angiotippreferably comprises an angiotip distal end and an angiotip proximalend, the angiotip distal end preferably having a diameter less than theangiotip proximal end.

4. Specific Embodiments in the Figures

Referring to FIGS. 1, 2A, and 2B, an apparatus that includes a braidedlocking wire is illustrated, which has features any one of which may befound in various specific embodiments, including both those that areshown in this specification and those that are not shown.

Referring to FIG. 1, an apparatus including a braided locking wire 46 isdepicted. A guide wire 12 serves as a directional device along whichother surgical devices 16 may be guided through a tortuous path throughthe blood vessels. The guide wire 12 may be manipulated through thecardiovascular system from an entry site, through a target site, and outan exit site. An angiotip 14 may be used as a distal end for acardiovascular device or other surgical device 16, so the diameterchange of the entire system is gradual and is less likely to tear intovessel walls. The angiotip 14 may be used to guide a cardiovasculardevice 16 within the blood vessel. The angiotip 14 and the guide wire 12are also capable of being frictionally engaged with each other, so thatthe angiotip 14 and guidewire 12 no longer move independently of oneanother. A braided locking wire 46 comprising a braided sheath 20 andcenter wire 22 is introduced to the inner cavity of the angiotip 14 whenthe braided sheath 20 is in its retracted state. A device such as theLead Locking Device (LLD EZ®) produced by Spectranetics® may be used asthe braided locking wire 46 (Spectranetics® product ref 518-062). Forexample, the LLD EZ® device may be used in combination with a 0.018 inchguide wire 12, (such as those commercially produced by Cook Medical,Abbott Laboratories, Terumo® Medical, and Boston Scientific) so that acurrently produced commercial angiotip 14 (such as those produced byCook Medical or Endologix, Inc.) with an inner cavity diameter of 0.038inches may be used without further modification. 14 The braided sheath20 is capable of expanding laterally to have a larger diameter than inits retracted state. Both the braided sheath 20 and center wire 22extend proximally from the angiotip 14 to a point outside the body nearthe entry site. The expanded braided sheath 20 will press the guide wire12 against the inner cavity surface of the angiotip 14, creatingfriction between the guide wire 12 and the angiotip 14. A protectivecatheter 18 may be used to shield the vessel walls from the thin guidewire 12, as too much pressure from pulling on the guide wire 12 wouldotherwise lacerate the vessels at the curves of the vessels. A proximallock 56 may be used to cause the cardiovascular device 16 and theangiotip 14 to move as a single unit in the proximal or distaldirection. The proximal lock 56 may be released when the device 16reaches the target site, so that the angiotip 14 and cardiovasculardevice 16 may move independently.

Referring to FIGS. 2A and 2B, an angiotip 14 comprising an inner cavity24 is depicted. FIG. 2A shows the angiotip 14 in the “unlocked”position, where the guide wire 12 and angiotip 14 are not frictionallyengaged. The guide wire 12 passes completely through the angiotip 14with a portion of the guide wire 12 located within the inner cavity 24of the angiotip 14. The braided locking wire 46 comprising a braidedsheath 20 and center wire 22 is introduced into the proximal end of theangiotip 14 in the braided locking wire's 46 refracted state. Thebraided locking wire 46 has a center wire 22 that is connected to thedistal end of the braided sheath 20. The center wire 22 and the braidedsheath 20 can be moved together as one unit or the braided sheath 20 canbe moved independently of the center wire 22 from the braided sheathproximal end 23 (See FIG. 1), causing the braided sheath 20 to expandoutwardly from the center wire 22 or retract inwardly back toward thecenter wire 22. When the braided sheath 20 is in the retracted position,it does not apply pressure to the guide wire 12, and the guide wire 12is capable of moving freely within the angiotip 14.

FIG. 2B shows the angiotip 14 in the “locked” position, where the guidewire 12 and the angiotip 14 are frictionally engaged by the braidedlocking wire 46. The proximal end of the braided sheath 20 may beadvanced distally towards the angiotip 14 while the center wire 22 isheld substantially in place. This will expand the diameter of thebraided sheath 20 within the angiotip 14, and the expanded braidedsheath 20 will press the guide wire 12 against the inner cavity surface54 of the angiotip 14 and partially or wholly limit the longitudinalmovement of the guide wire 12 within the angiotip 14. The guide wire 12and angiotip 14 will now be moved substantially together when one or theother is moved individually.

Referring to FIGS. 3 and 4, an apparatus that includes a jamming lockwire is illustrated, which has features any one of which may be found invarious specific embodiments, including both those that are shown inthis specification and those that are not shown.

Referring to FIG. 3, an apparatus including a jamming lock wire 26 isdepicted. A guide wire 12 serves as a directional device along whichother surgical devices 16 may be guided through a tortuous path throughthe blood vessels. The guide wire 12 is thin and may be manipulatedthrough the cardiovascular system from an entry site, through a targetsite, and out an exit site. An angiotip 14 may be used as a distal endfor a cardiovascular device or other surgical device 16, so the diameterchange of the entire system is gradual, and the device is less likely totear into vessel walls. The angiotip 14 may be used to guide acardiovascular device 16 within the blood vessel. The angiotip 14 andthe guide wire 12 are also capable of being frictionally engaged witheach other, so that the angiotip 14 and guidewire 12 no longer moveindependently of one another. A jamming lock wire 26 is introduced intothe inner cavity of the angiotip 14. The jamming lock wire 26 extendsproximally from the angiotip 14 to a point outside the body near theentry site. The jamming lock wire will press the guide wire 12 againstthe inner cavity surface of the angiotip 14, creating friction betweenthe guide wire 12 and the angiotip 14. A protective catheter 18 may beused to shield the vessel walls from the thin guide wire 12, as too muchpressure from pulling on the guide wire 12 may otherwise lacerate thevessels at the curves of the vessels. A proximal lock 56 may be used tocause the cardiovascular device 16 and the angiotip 14 to move as asingle unit in the proximal or distal direction. The proximal lock 56may be released when the device 16 reaches the target site so that theangiotip 14 and cardiovascular device 16 may move independently.

Referring now to FIG. 4, an angiotip 14 comprising a guide wire channel28 and a lock wire channel 30 is depicted. A portion of guide wire 12 isdisposed within the angiotip 14 while the rest of guide wire 12 extendsin both the proximal and distal directions out of the angiotip 14. Thejamming lock wire 26 is disposed within the angiotip 14 and extendsproximally to a location out of the body so it may be accessible to theoperating physician. The lock wire channel 30 may be connected to theguide wire channel 28 so that the jamming lock wire 26 passing axiallythrough the lock wire channel 30 may also radially enter the guide wirechannel 28. The guide wire channel 28 and the lock wire channel 30 maybe part of a single combined inner cavity 24 that both the guide wire 12and the jamming lock wire 26 may occupy (pictured). For example, twocommercially produced wires (such as those produced by Cook Medical,Abbott Laboratories, Terumo® Medical, and Boston Scientific) whosecombined diameters are equal to or slightly greater than the innercavity diameter of a commercially produced angiotip (such as thoseproduced by Cook Medical or Endologix, Inc.) may be used to jam bothwires in place. Alternatively, there may be a divider between the twochannels that is a part of the angiotip 14 (not pictured). For example,a commercially available angiotip (such as those produced by CookMedical or Endologix, Inc.) may be modified by drilling a second channelin the angiotip for a jamming lock wire to pass through. When thejamming lock wire 26 is advanced distally and axially to the end of thelock wire channel 30, it may be directed towards the guide wire channel28 (i.e. in a somewhat radial direction) and press against the guidewire 12. When the jamming lock wire 26 presses against the guide wire12, friction is created between the jamming lock wire 26 and the guidewire 12, as well as between the guide wire 12 and the inner cavitysurface 54 of the angiotip 14. The guide wire 12 and the angiotip 14 arenow frictionally engaged and may now be moved substantially togetherwhen one or the other is moved individually, particularly in a proximalor distal (axial) direction. The frictional engagement can be releasedby retracting the jamming lock wire 26 in the proximal direction so thatthe jamming lock wire 26 no longer presses against the guide wire 12.

Referring to FIGS. 5, 6A, and 6B, an apparatus that includes a cam lockis illustrated, which has features any one of which may be found invarious specific embodiments, including both those that are shown inthis specification and those that are not shown.

Referring to FIG. 5, an apparatus including a cam lock 32 is depicted. Aguide wire 12 serves as a directional device along which other surgicaldevices 16 may be guided through a tortuous path through the bloodvessels. The guide wire 12 is thin and may be manipulated through thecardiovascular system from an entry site, through a target site, and outan exit site. An angiotip 14 may be used as a distal end for acardiovascular device or other surgical device 16, so the diameterchange of the entire system is gradual, and the device is less likely totear into vessel walls. The angiotip 14 may be used to guide acardiovascular device 16 within the blood vessel. The angiotip 14 andthe guide wire 12 are also capable of being frictionally engaged witheach other, so that the angiotip 14 and guidewire 12 no longer moveindependently of one another. A cam lock 32 may be positioned within theangiotip 14, preferably within the inner cavity of the angiotip 14. Acam lock wire 34 may be attached to the cam lock 32 and extendproximally from within the angiotip 14 to a point outside the body nearthe entry site, so it may be accessible to the operating physician. Thecam lock 32 is located within the angiotip 14 and has a point ofrotation. The cam lock 32 can rotate about this point so that an edge ofthe cam lock 32 can press radially against the guide wire 12. Therotating motion is directed by the cam lock wire 34 so that advancingthe cam lock wire 34 axially in the distal direction rotates the camlock 32 so that the cam lock 32 presses against the guide wire 12. Thecam lock wire 34 may alternatively be attached to the cam lock 32 in away that retracting the cam lock wire 34 in the proximal directionrotates the cam lock 32 so that it presses against the guide wire 12(example diagram not depicted). A protective catheter 18 may be used toshield the vessel walls from the thin guide wire 12, as too muchpressure from pulling on the guide wire 12 might otherwise lacerate thevessels at the curves of the vessels. A proximal lock 56 may be used tocause the cardiovascular device 16 and the angiotip 14 to move as asingle unit in the proximal or distal direction. The proximal lock 56may be released when the device 16 reaches the target site so that theangiotip 14 and cardiovascular device 16 may move independently.

Referring to FIGS. 6A and 6B, an angiotip 14 comprising a cam lock 32 isdepicted. FIG. 6A shows the angiotip 14 in the “unlocked” position,where the guide wire 12 and angiotip 14 are not frictionally engaged.The guide wire 12 passes completely through the inner cavity 24 of theangiotip 14 with a portion of the guide wire 12 located within the innercavity of the angiotip 14. The cam lock 32 is rotated to an angle whereit does not press against the guide wire 12. The rotation of the camlock 32 is controlled by the cam lock wire 34, so that when the cam lockwire 34 is retracted in the proximal direction, the cam lock 32 does notpress the guide wire 12 against the inner cavity surface 54 (aspictured). The rotation of the cam lock 32 can alternately be controlledby the cam lock wire 34 so that when the cam lock wire 34 is advanceddistally, the cam lock 32 does not press against the guide wire 12(example not depicted). When the cam lock 32 is not pressing against theguide wire 12, the guide wire 12 is capable of moving freely within theangiotip 14.

FIG. 6B shows the angiotip 14 in the “locked” position, where the guidewire 12 and the angiotip 14 are frictionally engaged due to the cam lock32 pressing the guidewire 12 against the inner cavity surface 54 of theangiotip 14. The rotation of the cam lock 32 is controlled by the camlock wire 34, so that when the cam lock wire 34 is advanced in thedistal direction, the cam lock 32 may press the guide wire 12 againstthe inner cavity surface 54 of the angiotip 14 and partially or whollylimit the longitudinal movement of the guide wire 12 within the innercavity 24 of the angiotip 14. The cam lock 32 may press against theguide wire 12, and friction may be created between the cam lock 32 andthe guide wire 12, as well as between the guide wire 12 and the innercavity surface 54 of the angiotip 14. The guide wire 12 and angiotip 14may now be frictionally engaged and may be moved substantially togetherwhen one or the other is moved individually.

Referring to FIGS. 7 and 8, an apparatus that includes a twisting lockis illustrated, which has features any one of which may be found invarious specific embodiments, including both those that are shown inthis specification and those that are not shown.

Referring to FIG. 7, an apparatus including a twisting lock 50 isdepicted. A guide wire 12 serves as a directional device along whichother surgical devices 16 may be guided through a tortuous path throughthe blood vessels. The guide wire 12 is thin and may be manipulatedthrough the cardiovascular system from an entry site, through a targetsite, and out an exit site. An angiotip 14 may be used as a distal endfor a cardiovascular device or other surgical device 16, so the diameterchange of the entire system is gradual, and the device is less likely totear into vessel walls. The angiotip 14 may be used to guide acardiovascular device 16 within the blood vessel. The angiotip 14 andthe guide wire 12 are also capable of being frictionally engaged witheach other, so that the angiotip 14 and guidewire 12 no longer moveindependently of one another. A twisting lock 50 is positioned withinand coupled to the angiotip 14. The twisting lock 50 is such that whenit is rotated either clockwise or counterclockwise, the inner diameterof the twisting lock 50 may decrease. The inner surface of the twistinglock 50 may then press on the guide wire 12, thus creating frictionbetween the guide wire 12 and the twisting lock 50. The twisting lock 50may be coupled to either the device 16 or a sheath 52, so that turningon the sheath 52 at the proximal end will turn the twisting lock 50within the angiotip 14. The sheath 52 may extend proximally out of thebody so that it may be accessible to the operating physician, coupled toanother object that may extend proximally out of the body, or there maybe other means of rotating the sheath 52 that are well known in the art.Alternately, there may be another device or series of devices coupled tothe twisting lock 50 that extend proximally out of the body, so thatrotating this device or devices also rotates the twisting lock 50 withinthe angiotip 14 (example not pictured). A protective catheter 18 may beused to shield the vessel walls from the thin guide wire 12, as too muchpressure from pulling on the guide wire 12 would otherwise lacerate thevessels at the curves of the vessels. A proximal lock 56 may be used tocause the cardiovascular device 16 and the angiotip 14 to move as asingle unit in the proximal or distal direction. The proximal lock 56may be released when the device 16 reaches the target site so that theangiotip 14 and cardiovascular device 16 may move independently.

Referring now to FIG. 8, an angiotip 14 comprising a twisting lock 50 isdepicted. The twisting lock 50 is positioned within the angiotip 14, butit is free to rotate within the angiotip 14. The twisting lock 50 iscoupled to the device 16 or sheath 52, so that twisting the device 16 orsheath 52 about its longitudinal axis will also turn the twisting lock50 about its axis. Alternately, there may be another device or series ofdevices coupled to the twisting lock 50 so that rotating these device(s)would also rotate the twisting lock 50 within the angiotip 14. Rotatingthe twisting lock 50 may cause the inner diameter of the twisting lock50 to decrease. The inner surface of the twisting lock 50 may press onthe guide wire 12. The longitudinal movement of the guide wire 12 may belimited within the angiotip 14 due to friction created between thetwisting lock 50 and the guide wire 12. Once the twisting lock 50 isrotated and presses against the guide wire 12, pulling the guide wire 12in a distal direction may now also move the angiotip 14 in a distaldirection, as the twisting lock 50 is coupled to the angiotip 14. Thetwisting lock 50 may be turned in the opposite direction to release thepressure on the guide wire 12 to release the frictional engagement andallow the guide wire 12 to move freely through the angiotip 14.

Referring to FIGS. 9A, 9B, 9C, and 9D, the movements of several specificembodiments through the body are generally depicted in a step-wisemanner.

Referring to FIG. 9A, a guide wire 12 having both a proximal end and adistal end is introduced into the body via an entrance site 36 which maybe positioned on a femoral artery 44. The guide wire 12 is directedthrough the cardiovascular system to a location (for example, thedescending aorta) that is the target site 42 of the surgery, which maybe exploratory, diagnostic, or therapeutic in nature. The guide wire 12is then directed past the target site 42 to a point distal the targetlocation. The guide wire will then be directed out of the body via anexit site 38 which may be positioned on a brachial artery 40.Alternatively, the target site may be located within the heart (e.g. theaortic valve), the guide wire may be fed out through the heart (e.g. theapex), and the exit site may be through the left chest wall (example notpictured). The guide wire 12 may now protrude from the body in twoplaces, at the exit site 38 and the entrance site 36. A proximal lock 56may be positioned outside of the body near the entrance site 36 and maybe used to cause the cardiovascular device 16 and the angiotip 14 tomove as a single unit in the proximal or distal directions.

Referring now to FIG. 9B, an angiotip 14 is introduced into the bodythrough the entrance site 36 by sliding the angiotip 14 along the guidewire 12. The angiotip 14 may be advanced by using a pusher rod 48 toapply force behind the angiotip 14 and direct the angiotip 14 in adistal direction towards the target site 42 and away from the entrancesite 36. The guide wire 12 may be held in substantially in the sameposition within the body as the angiotip 14 slides along the guide wire12. Alternatively, this step may be omitted, i.e. the angiotip 14 is notintroduced into the body nor advanced using the pusher rod 48. Theangiotip 14 and optional cardiovascular device 16 may be introduced intothe body through the exit site 38 instead of the entrance site 36(example diagram not pictured). In this case, the point of origin wouldbe the exit site 38 and sliding in the distal direction would involvemoving towards the target site 42 and the entrance site 36 and away fromthe exit site 38.

Referring now to FIG. 9C, the angiotip 14 may be positioned somewheredistal to the entrance site 36 and proximal the target site 42 and theexit site 38. The angiotip 14 may alternately be positioned stilloutside the body near the entrance site 36 or the exit site 38 (examplediagram not pictured). A locking wire 58 is now introduced into thethrough entrance site 36 and up to the angiotip 14. The locking wire 58may alternatively be introduced to the angiotip 14 when the angiotip 14is still outside of the body (example diagram not pictured). The innercavity 24 of the angiotip 14 now contains the guide wire 12 and thelocking wire 58 placed adjacent to one another. The locking wire 58 mayextend from within the angiotip 14 to a position outside of the body, soit may be accessible to the operating physician. The locking wire 58 maycause the guidewire 12 to press against the angiotip 14 in one or moreof the several ways described in the specification, so that the guidewire 12 is frictionally engaged with the angiotip 14. A protectivecatheter 18 is introduced into the body over the guide wire 12 via theexit site 38. The protective catheter 18 is advanced in the proximaldirection towards the entrance site 36 until it reaches the angiotip 14.The protective catheter 18 extends from the distal end of the angiotip14 over the guide wire 12, exits the body at the exit site 38, and mayextend over the guide wire 12 outside of the body. The protectivecatheter 18 is in place to prevent a “cheese cutter” effect by the guidewire 12, where too much pressure from pulling on the thin guide wire 12might otherwise lacerate the vessels at curves in the vessels.

Referring now to FIG. 9D, the frictionally engaged guide wire 12,protective catheter 18, locking wire 58, and angiotip 14 are now capableof being pulled as a single unit from the guide wire's distal end in thedistal direction. The cardiovascular device 16 may still be coupled tothe angiotip 14 by the proximal lock 56. The angiotip 14 will bedirected distally towards the target site 42. The cardiovascular device16 may also be moved distally with the angiotip 14, guide wire 12,protective catheter 18, and locking wire 58. The angiotip 14 andcardiovascular device 16 may now be advanced distally to the target site42 by pulling a portion of the guide wire 12 that is located distallyfrom the angiotip 14, thus exerting a pulling force on the angiotip 14where it is frictionally engaged with the guide wire 12. This pullingforce may be used alone to direct the angiotip 14 and cardiovasculardevice 16, or in combination with a pushing force exerted at a locationproximal from the angiotip 14, including from a position outside of thebody near the entrance site 36. Once the angiotip 14 and cardiovasculardevice 16 are in place at the target site 42, the frictional engagementon the guide wire 12 and angiotip 14 may be removed by removing thepressure caused by the locking wire 58. The guide wire 12 and angiotip14 are no longer frictionally engaged and may now be moved independentlyof one another. The proximal lock 56 may be removed after thecardiovascular device 16 has reached the target site, so that theangiotip 14 and the cardiovascular device 16 may now move independentlyof one another.

What is claimed as the invention is:
 1. A vascular delivery devicecomprising: a first wire having a first proximal wire end and a firstdistal wire end; a second wire having a second proximal wire end and asecond distal wire end; and a housing having an inner cavity, an innercavity surface, a distal face, and a proximal face; wherein: the firstwire is capable of being introduced into a blood vessel having a distalvessel end and a proximal vessel end by sliding over a second wire; thefirst wire is capable of being introduced into the inner cavity of thehousing; at least a portion of the first wire is capable of expandingwithin the inner cavity of the housing to provide an expanded portion ofthe first wire such that the expanded portion of the first wire makescontact with the inner cavity surface of the housing and the second wireand restricts longitudinal movement of the second wire with respect tothe housing; the second wire is capable of being frictionally engagedwith the housing by causing the portion of the first wire to expandwithin the inner cavity of the housing such that the portion of thefirst wire contacts both the second wire and the inner cavity surface ofthe housing and restricts longitudinal movement of the second wire withrespect to the housing; the second wire is a guide wire; the second wireis capable of being pulled through the blood vessel in the direction ofthe distal vessel end; and pulling of the second wire pulls the housingthrough the blood vessel in the direction of the distal vessel end.
 2. Avascular delivery device comprising: a first wire having a firstproximal wire end and a first distal wire end; a second wire having asecond proximal wire end and a second distal wire end; and a housinghaving an inner cavity, an inner cavity surface, a distal housing end,and a proximal housing end; wherein: the housing is capable of slidingalong the second wire in a direction away from the second proximal wireend and toward the second distal wire end; the housing is beveled suchthat the distal housing end has a smaller surface area than the proximalhousing end; the first wire is capable of being introduced into theinner cavity of the housing by passing the first distal wire end into ablood vessel having a proximal vessel end and a distal vessel endthrough an opening nearer to the proximal vessel end than the distalvessel end such that at least a portion of the first distal wire end ispositioned within the inner cavity of the housing, the second wire iscapable of being frictionally engaged with the housing by causing atleast a portion of the first wire to expand within the inner cavity ofthe housing such that the portion of the first wire contacts the secondwire and the inner cavity surface of the housing and restrictslongitudinal movement of the second wire with respect to the housing;and the second wire is capable of being pulled through the blood vesselin the direction of the distal vessel end, wherein pulling of the secondwire pulls the housing through the blood vessel in the direction of thedistal vessel end.
 3. A vascular delivery device comprising: a firstwire having a first proximal wire end and a first distal wire end; asecond wire having a second proximal wire end and a second distal wireend; a housing having an inner cavity, an inner cavity surface, a distalhousing end, and a proximal housing end; and a cardiovascular devicecoupled to the housing; wherein: the housing is capable of sliding alongthe second wire in a direction away from the second proximal wire endand toward the second distal wire end; the first wire is capable ofbeing introduced into the inner cavity of the housing by passing thefirst distal wire end into a blood vessel having a proximal vessel endand a distal vessel end through an opening nearer to the proximal vesselend than the distal vessel end such that at least a portion of the firstdistal wire end is positioned within the inner cavity of the housing,the second wire is capable of being frictionally engaged with thehousing by causing at least a portion of the first wire to expand withinthe inner cavity of the housing such that the portion of the first wirecontacts the second wire and the inner cavity surface of the housing andrestricts longitudinal movement of the second wire with respect to thehousing; the second wire is capable of being pulled through the bloodvessel in the direction of the distal vessel end, wherein pulling of thesecond wire pulls the housing through the blood vessel in the directionof the distal vessel end; and the cardiovascular device is capable ofuncoupling from the housing and capable of being deployed.
 4. A vasculardelivery device comprising: a first wire having a first proximal wireend and a first distal wire end; a second wire having a second proximalwire end and a second distal wire end; a cardiovascular device; and ahousing having an inner cavity, an inner cavity surface, a distal face,and a proximal face; wherein: the first wire is capable of beingintroduced into a blood vessel by sliding over a second wire; the firstwire is capable of being introduced into the inner cavity of thehousing; at least a portion of the first wire is capable of expandingwithin the inner cavity of the housing to provide an expanded portion ofthe first wire such that the expanded portion of the first wire makescontact with the inner cavity surface of the housing and the second wireand restricts longitudinal movement of the second wire with respect tothe housing; the second wire is capable of being frictionally engagedwith the housing by causing the portion of the first wire to expandwithin the inner cavity of the housing such that the portion of thefirst wire contacts both the second wire and the inner cavity surface ofthe housing and restricts longitudinal movement of the second wire withrespect to the housing; the second wire is a guide wire; and the firstwire, the second wire, the housing, and the cardiovascular device arecapable of being pulled as a single unit from the second distal wire endin a distal direction when the second wire is frictionally engaged withthe housing.